The innovative phenylcapsaicin
Our science for better animal health
The purity and concentration of aXiphen® are exceptional, making it reliable and efficient for high-volume industrial production. aXiphen® is not persistent, bioaccumulate or toxic and leaves no trace in the tissues. It shows no negative effects on the animal’s health, while EPEF (European production efficiency factor) is considerably improved. The pungency of Phenylcapsaicin is greatly reduced in aXiphen® due to its encapsulation in a proprietary fat matrix. Thanks to this formulation, it can be easily included in feed processes and produces consistent results in a variety of farming operations.
Phenylcapsaicin –
a new proprietary analogue of capsaicin
aXiphen® is based on an innovative molecule “Phenyl-capsaicin” which is an analogue to capsaicin. Phenylcapsaicin is a proprietary molecule where a naturally occurring phenyl group, bridged by a triple bond, has been used to stabilise nature identical capsaicin. These modifications in the molecular structure offers several benefits compared to its naturally occurring analogue.
Zoomed down to a molecular level, aXiphen® shows similar bioactivity as other TRPV1-agonists such as natural capsaicin in several studies. Activating the TRPV1receptor, a non-selective cation channel has been implicated in various physiological processes, including the regulation of blood pressure, inflammation, and the release of certain neurotransmitters and neuropeptides and perhaps the most commonly known effects as the perception of pain and heat. The structural similarities and differences between Phenylcapsacin and capsaicin lead to an improved potent product with very interesting properties.
Microencapsulation
Phenylcapsaicin activates the capsaicin receptor, the origin of the pungent hot feeling in chili, which is not always desirable. To control the pungency, aXichem has developed a unique microencapsulation, engineered for specific release resulting in the formulation of aXiphen. The product is packaged in an easy to handle formulation with low percentage of the active compound for commercializing purposes.
aXiphen® process description
1) An emulsion of Phenylcapsaicin in melted refined rapeseed oil is sprayed into a stream of cold air in a cooling tower.
2) The droplets solidifies into spherical particles.
3) Oversized particles are sieved and removed.
4) Particles are packaged into ready product.